By atherosclerosis the inside of the arteries are thickened, hardened and stiffened, causing the space for blood flow to be narrowed or closed. This will decrease the oxygen supply to local or distant tissues.
The primary symptom of this is pain, poor organ function and bad general condition. The further consequences are tissue damage, sometimes acute damage because by stop of blood flow caused by a sudden blood clot formed in the narrowed areas.
THE MECHANISMS AND CAUSES OF ATHEROSCLEROSIS
The inner walls of the arteries consist of an innermost layer of endothelial cells (surface cells) and under these a layer of smooth muscle cells. The changes by atherosclerosis take place under the endothelial cells and in this muscle layer. The changes consist of: A certain degree of cell proliferation or tumour, gathering of cholesterol and fat. Deposition of calcium salts. Deposition of blood elements like fibrin.
The deposits are called atherosclerotic plaque or atheroma. Atherosclerosis is one of several types of artery thickening and hardening. A common name for thickening and hardening of arteries is “arteriosclerosis”. Often atherosclerosis...