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A SCIENTIST’S 20-YEAR UNFINISHED JOURNEY TO TREAT HBV MAY OPEN THE DOOR TO A NEW CLASS OF FLEXIBLE VACCINES
While preparing a lecture in biochemistry and virology for his graduate students at the University of Alberta in the early 1980s, Dr. Lorne Tyrrell ran across a study just published in the medical journal, Cell. The research by William Mason and Jesse Summers, entitled Replication of Hepatitis B, discussed their study of the hepatitis B virus in infected duck liver.
After studying their duck model theory, Tyrrell speculated if the hepatitis B virus (HBV) might be susceptible to antiviral agents, and consulted with a colleague, who specialized in nucleoside chemistry. Both medical professors became excited about the possibility of inhibiting the HBV virus with nucleoside analogues. Thus began the infectious disease specialists first leg of a journey, which led to the use of lamivudine as a therapy for chronic HBV infections.
More than 350 million people across the world, especially in Asia, now had new hope, some for their lifelong infections...
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