Do you know why and how your nose could feel itching and sensitive? The substance that causes itching and sensitive of your nose is called allergen. These include pollen, mold, dust mites, certain foods, latex, animal dander, and others. These allergens sensitize the nasal mucosal membrane through a sensitization process, which typically involves a few types of cell in our body, such as macrophage, lymphocyte and mast cell. In the beginning of the sensitization, allergens penetrate through the mucosal surface in our nasal passage. The easiness of the allergens penetrate through the mucosal surface is due to the deficiency of IgA antibodies, which main function is eliminating micro organisms that adhere to the mucosal surface. Usually, patients, who allergic to the allergen, have lower level of IgA antibodies.
The second step of the sensitization process is scavenging of the allergen by the macrophage cell. Macrophage cell is the large scavenger cell in the blood, whose function is eating up antigen, which is from outside of our body. During the scavenging process, macrophage cells also pass information about the invasion of foreign antigen to the lymphocyte cell, which...
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